Hey Devin! My serial WebLit site's running on Drupal too (linked in my sig), and it took awhile to find a premade theme I liked. If you're a dab hand at theme hacking, I suggest starting with the Zen theming kit (it's on drupal.org) and working off of that. Or just look for another free theme there and then hack it up until you come up with something nice. If you need help with Drupal I really suggest asking MeiLin Miranda about it - she's a font of knowledge when it comes to Drupal. (She's on WFG and is also easily findable at meilinmiranda.com ) I've been working with Drupal for awhile but I'm more the graphics person than the web admin.
An important thing to do to a Drupal site is give it a different front page than the default recent updates page. I think there's a module called Front Page for that on drupal.org. You can set an info page up front instead that introduces people to your story and gives them a little information about you, some story hooks, art, recipes, whatever. Also, if you haven't installed the Advanced Forum Module yet, do so. It's much better than the default forum module. (Unless the Advanced Forum came with your Drupal install, in which case disregard this statement. I first set up Drupal about six months ago and they update pretty swiftly.)
I'm gonna withhold specific advice for now because any more advice really depends on the base theme you pick. Remember to go for readability and also remember that themes can be very flexible when you pick at the graphics. As an experiment I found this: http://drupal.org/project/dreamy and turned it into this: http://irk.infernalshenanigans.net/
Going for a theme that lets you drop in a header graphic at the top can really help establish a good look for the site, and something to build off of. If you get really serious about Drupal, I suggest this book: http://www.drupalbook.com/
I'm working with it in tandem with this book: http://www.csswebdevelopment.com/ I'm learning CSS now, and pairing that book up with the Drupal book's big section on theming has made a lot of things click for me.
Drupal is a big time investment - I REALLY consider it worth it if you're willing to go the long haul on it. You'll definitely become a developer in the process. Wordpress is more user-friendly, but you can't do as much with it as you can do with Drupal. BOTH have a very big, supportive community and a large library of themes to pick from. (By the way, you can also take any CSS template you find and apply it to Drupal with some minimal hacking. That Drupal book goes into detail on how to do it, and it's basic enough that I understood it on the first read-through.)