A few things I've learned:
Pick a schedule where the day before you post is expendable. You're going to need it.
You can have story. You can have comedy/horror/philosophy. The problem is finding a way to make them work together.
Pop culture and stories based on something topical aren't timeless. They'll lose a lot of their meaning months down the line unless it's something with some sticking power to it, like "My name is Inigo Montoya. You killed my father. Prepare to die."
Know what slot your story is trying to fit into. Some people like epic but depressing stories like Worm. Some people like their stories lighter like Legion of Nothing. Some even like the more South Park-like depths of serials and enjoy World Domination in Retrospect. Just as Godzilla isn't being remade to try and sweep the Oscars, you should be aware of who you're going into this to hook as an audience and know that you're not going to appeal to everyone, so don't feel so bad.
And finally, to quote the movie Real Genius: "Always...never...check your references. I think the young people like it when I 'get down' verbally, don't you?"